Vita Sciences Topical B12 was developed by leading scientists in their field. Our Topical B12 has superior absorption using patented technology, and is the original Topical B-12 on the market. Apply a new B12 Patch to a clean and dry area of the skin behind the ear lobe on the neck or on the inner part of your wrist. Firmly press adhesive side to skin and leave the patch in place for up to 24 hours. The recommended use is one patch worn up to 24 hrs (each patch contains 1000 mcg of B12) per week. A month supply contains 4 patches. One patch is approximately the size of a dime. Do not apply to damaged (wound, abrasion, sores, or rash) or sensitive skin. Only use one patch at a time. If pregnant or nursing, ask a health professional before use. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. If you experience difficulty with adhesion (based on skin type etc.) you may use a band-aid or medical tape over the patch.